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What the Nile Reveals About Modern Metabolic Health

What the Nile Reveals About Modern Metabolic Health

I’m writing this blog while cruising south (upstream) on the Nile River, watching the shoreline drift by in its slow, ancient rhythm. It is impossible to be here and not feel the weight of history. This rive…
Dr. Perlmutter’s Views on the 2025–2030 Dietary Guidelines for Americans

Dr. Perlmutter’s Views on the 2025–2030 Dietary Guidelines for Americans

For decades, federal dietary guidance has struggled to keep pace with what clinicians and researchers have observed on the front lines of chronic disease. The newly released Dietary Guidelines for Americans,…
Why Berberine Earned a Place in My Daily Supplement Stack

Why Berberine Earned a Place in My Daily Supplement Stack

When people ask me about supplements, I always come back to one foundational principle: if it doesn’t meaningfully improve metabolic health, it probably doesn’t belong in my routine. That’s exactly why berbe…
The Brain’s Immune System and a Breakthrough That Changes Everything

The Brain’s Immune System and a Breakthrough That Changes Everything

In my recent lectures, podcasts, and blog posts, I’ve been emphasizing a message that is still surprisingly new to many people: the health of the brain is inseparable from the health of its immune system. At…
Why Redefining Alzheimer’s as a “Biological” Condition Is Harmful, and Why the International Working Group Is Pushing Back

Why Redefining Alzheimer’s as a “Biological” Condition Is Harmful, and Why the International Working Group Is Pushing Back

In late 2024, the Alzheimer’s Association (AA) introduced new diagnostic criteria suggesting that Alzheimer’s disease can be identified in people who are completely cognitively normal, solely on the basis of…
Can Coffee Actually Reduce Atrial Fibrillation Recurrence?

Can Coffee Actually Reduce Atrial Fibrillation Recurrence?

A New Randomized Trial Says Yes. For decades, patients with atrial fibrillation (AF) have been told that caffeine is a trigger for arrhythmias. Many clinicians have reinforced this idea, urging patients to …
Pickleball – Know the Risks Before You Play

Pickleball – Know the Risks Before You Play

Pickleball has certainly become a thing. It’s the perfect blend of fun, movement, and social engagement, especially in retirement communities like where I live. One player captured the appeal succinctly in a…
Paraquat and Parkinson’s. Be Aware!

Paraquat and Parkinson’s. Be Aware!

Paraquat is one of the most toxic herbicides still in common use, and it’s an underappreciated threat to the human brain. A growing body of epidemiologic and experimental research links chronic paraquat expo…
New Medication Associated with a 50% Risk Reduction for Dementia!

New Medication Associated with a 50% Risk Reduction for Dementia!

In the context of the lack of any meaningful treatment for dementia, including Alzheimer’s disease, the recent discovery of a new medication that has been shown to be associated with dementia risk reductio…
How Food Choices Can Override Alzheimer’s Risk

How Food Choices Can Override Alzheimer’s Risk

With the increasing availability of direct-to-consumer genetic testing, more and more people are learning their APOE status, and for many, this discovery brings both curiosity and concern. Carrying one or tw…