AGEs, Inflammation, and Hippocampal Atrophy

You’ve heard me speak extensively about the toxic role of sugar and carbohydrates in terms of brain health. I’ve even gone so far as to say that elevated blood sugar is correlated with shrinkage of the brain. Why would I say that? In this video we look at a study associating shrinkage of the hippocampus with elevated blood sugar. We now know that when blood sugar is elevated, it binds to protein and forms what is called AGEs or Advanced Glycation End Products. These AGEs then turn on inflammation by leading to leakiness of the gut, which is what affects the brain the most. This is the toxic effect of blood sugar as it relates to the brain.