Category: Brain Health

In this section you will find everything pertaining to the subject of brain health and preventing cognitive decline. Whether you are wondering how to prevent Alzheimer’s or what to eat when experiencing brain fog, this Brain Health section explores the connection between proper nutrition and brain preservation and development.

Some posts to get you started:
Reversing Alzheimer’s Disease
Food For Thought

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Choosing Your Cognitive Destiny

In 1998, Dr. Peter Eriksson published a groundbreaking report in the journal Nature Medicine in which he described, for the first time, that the process of growing new brain cells, neurogenesis, occurs in humans. That was only 22 years ago. Prior to his publication it was generally assumed that humans developed brain cells up until our late teen years and it was downhill after that.

We now know that a person retains the ability to grow new brain cells throughout his/her entire lifetime. Importantly, it is now clear that there are various things we can do that will directly enhance this process of neurogenesis. Among the most potent stimuli triggering the growth of new brain cells are physical exercise, a ketogenic diet, whole coffee fruit extract, and there is now some pretty compelling data supporting the role of a particular species of mushroom, Hericium erinaceus (more commonly known as lion’s mane), in causing neurogenesis. Continue reading

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Sleep Duration and Cognitive Decline

By the Dr. Perlmutter Team

When asked what supplements I recommend for optimal health, I occasionally reply, “sleep.” Sleep is powerful on so many levels in terms of health outcomes. We know that sleep duration and quality impact inflammation, what and how much we eat, hormone balance, decision-making, mood states, and much more.

An interesting study on sleep recently appeared in one of the publications of the American Medical Association called JAMA Network Open. The researchers behind the study sought to investigate the association between sleep duration and cognitive decline. They analyzed data from 20,065 total participants in two cohort studies, one in the United Kingdom, The English Longitudinal Study of Ageing (ELSA), and one in China, the China Health and Retirement Longitudinal Study (CHARLS). The ELSA sample included people 50 years or older and the CHARLS sample included people 45 years or older. Continue reading

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How A Keto Program Helps Parkinson’s Disease

These days so much is being written about the health benefits of lifestyle and nutrition strategies that produce ketosis. Indeed, actually treating certain conditions is now a fair-game discussion because of the robust scientific support being generated from institutions around the world.

I have previously presented information detailing the therapeutic benefit of a ketogenic lifestyle for issues like diabetes (both types 1 and 2), dementia, metabolic syndrome, and obesity. To be sure, there’s some outstanding work being done that demonstrates the effectiveness of a ketogenic program in Parkinson’s disease (PD). And one of the pioneers in studying the ketogenic diet in PD is Dr. Matthew Phillips, a neurologist in New Zealand who we’ve previously featured on The Empowering Neurologist. More recently, I had the opportunity to co-author, along with Dr. Phillips, a book chapter focused on the use of a ketogenic diet as an actual therapeutic intervention for Parkinson’s disease. Continue reading

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Diet and Depression: An Updated Perspective

By Dr. Austin Perlmutter

In conventional medical practice, the connection between diet and mood seems barely, if ever, mentioned. Depression is deemed a disease of the mind, or of the brain, treatable with psychotherapy or potent pharmaceuticals. In the latter, the focus seems primarily on modulating neurotransmitters like dopamine, serotonin, and norepinephrine.

Yet in the last several decades, there’s also been a push to revitalize dietary interventions for mood, especially for depression. Some have advocated strongly that food-based therapy is the solution to most health issues including mood disorders. But what does the current research in this field actually say, and are we interpreting it correctly? Continue reading

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Alzheimer’s Prevention Strategies Validated

Over the past decade we have been vigorously promoting the concept of Alzheimer’s prevention. Alzheimer’s disease is devastating, not just for the patient, but for families and loved ones as well. And let me be candid: watching my father succumb to Alzheimer’s was the most emotionally challenging experience of my life. Not only that, it also served to strengthen my resolve to do whatever I can to continue to raise awareness of the science that supports the notion that our lifestyle choices do indeed play an important role in determining our risk for this disease – a disease for which there is no meaningful treatment whatsoever. Continue reading

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Fructose, a “Safer Sugar”?

Lately, in an apparent attempt to push back from the negativity surrounding high fructose corn syrup, there seems to be an increase in the number of articles published touting the advantages of fructose as a “safer sugar.” The main point that is so often emphasized is that unlike glucose, fructose does not seem to increase insulin. Increasing insulin, which is how our bodies cope with increased glucose levels, may, when it’s constantly challenged, lead to a state in which we tend to lose our sensitivity to insulin. This means that with time, on a diet that constantly raises our glucose levels, insulin becomes less effective. Losing insulin sensitivity or becoming “insulin resistant” is not only associated with elevated blood sugar and subsequent diabetes, but also a fairly extensive list of chronic degenerative conditions that we want to do our best to avoid like coronary artery disease and Alzheimer’s. Continue reading

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You Can Choose to Lower Your Alzheimer’s Risk!

A central theme of our outreach messaging over the past decade centers on the role of our everyday lifestyle decisions in influencing the health destiny of our brains. As many of you know, we recently produced a docuseries Alzheimer’s – The Science of Prevention that reveals how our most well-respected scientific journals are making it very clear that each of us is truly the architect of our cognitive health destiny. We reveal exactly what we need to be doing day to day to meaningfully increase our chances of a life without Alzheimer’s disease.

And to bring everyone right up to date on the science, I’d like to discuss a study just published in the prestigious journal Neurology. Continue reading

The Empowering Neurologist – David Perlmutter, M.D. and Dr. Dale Bredesen

The Empowering Neurologist – David Perlmutter, M.D. and Dr. Dale Bredesen


It’s exciting to watch new developments in medicine, especially when new treatments for diseases are developed. Unfortunately, there is no treatment that has any merit for Alzheimer’s disease. Think of it, this disease that affects close to 5.8 million Americans is a disease for which we have no meaningful treatment whatsoever.

As many of you know, Dr. Dale Bredesen has pioneered a novel approach to Alzheimer’s disease. Rather than offering up a single treatment, he has created a multi-pronged program that is proving successful in reversing this disease. Yes, I’ll repeat, this program has reversed Alzheimer’s disease. Continue reading

The Empowering Neurologist – David Perlmutter, M.D., and Dr. Uma Naidoo

The Empowering Neurologist – David Perlmutter, M.D., and Dr. Uma Naidoo


What an exciting and important presentation we have for you today. For many years we have been providing information focused on the pivotal role of nutritional choices as they relate to the brain, mostly in the context of neurodegenerative conditions like Alzheimer’s disease. Today, we’re going to explore how our nutritional choices actually impact us from a mood perspective with our very special guest, Dr. Uma Naidoo. Let me tell you a bit more about her.

Michelin-starred chef David Bouley described Dr. Uma Naidoo as the world’s first “triple threat” in the food as medicine space: She is a Harvard-trained psychiatrist, professional chef who graduated with her culinary schools’ most coveted award, and a nutrition specialist. Her niche work is in Nutritional Psychiatry and she is regarded both nationally and internationally as a medical pioneer in this field.

In her role as a Clinical Scientist, Dr. Naidoo founded and directs the first hospital-based clinical service in Nutritional Psychiatry in the USA. She is the Director of Nutritional and Lifestyle Psychiatry at Massachusetts General Hospital (MGH) & Director of Nutritional Psychiatry at the Massachusetts General Hospital Academy while serving on the faculty at Harvard Medical School.

Continue reading

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3 Ways to Care for Your Brain in a Pandemic

By Dr. Austin Perlmutter

In the wake of the global spread of the 2019 coronavirus (COVID-19), many of us have started to think more carefully about our health. How can we reduce our risk of infection and of infecting others? How can we improve our immune function? What might the virus do to our lungs, heart and blood vessels? But while these questions are very important, it’s also critical to consider how a pandemic affects our brains and how to guard them against this damage. Specifically, we need to be considering strategies to protect our mental and cognitive health.

We’ve long known that mental health suffers in periods of high stress. So it’s no surprise that the current pandemic has been linked to a spike in feelings of anxiety and depression. A troubling May 2020 survey reported that over 34% of Americans are now experiencing these symptoms. This comes at a time when the world is already experiencing an epidemic of mental illness. Continue reading