In this section you will find everything pertaining to the subject of gut health and the health of the microbiome, and how it impacts disease. Whether you want to discover what it means to have a leaky gut, how your waistline impacts your brain, or to understand the difference between prebiotics and probiotics, this Gut Health section explores everything you need to know about nutrition, gut health, and the ramifications for the fate of your brain.
Category: Gut Health
By: The Dr. Perlmutter Team
One of the most exciting developments in lifestyle science over the last decade has been the sharpening focus on the central role that our resident microbes (bacteria) play in regulating overall health. These microbes, together with their genetic material and metabolic byproducts make up what is collectively known as the microbiome. It is becoming readily apparent that the trillions of microbes living on and within us play a fundamental role in almost all of the systems of the body. Even as recently as 10-20 years ago, we did not understand the extent to which the gut microbiome can influence a person’s mood, regulate appetite, produce essential vitamins, regulate the immune system, and influence systemic inflammation.
Today’s interview is with Lisa Mosconi, PhD. She is the associate director of the Alzheimer’s Prevention Clinic at Weil Cornell Medical College in New York. Prior to that she served as the director of the Nutrition and Brain Fitness Lab at New York University, School of Medicine.
Dr. Mosconi holds a dual PhD degree in neuroscience as well as nuclear medicine from the University of Florence, Italy, and is board-certified in integrative nutrition. Continue reading
As I’m sure you’re aware, we spend a lot of time in this forum discussing how the health of the brain is impacted by the health of the gut, the gut-brain connection. Made clear by the latest science, this is a powerful relationship that has ramifications which affect our risk for myriad number of diseases, including Alzheimer’s, a disease for which there is no cure.
By: The Dr. Perlmutter Team
What does it mean to have a healthy brain?
It means having a brain that is readily capable of performing all of its vital functions. This includes basic functions, like regulating the involuntary functions of the autonomic nervous system, and higher-level functions, such as facilitating cognition and decision-making, and coordinating fine and gross motor skills. While the brain is necessarily an incredibly complex organ, the process of neuroplasticity, which describes the brain’s ability to undergo physical and chemical changes in response to stimuli, affords us a significant degree of control over the health of our brain. In other words, the lifestyle choices we make today have a very real impact on our brain’s current and future health; whether that impact is positive or negative depends on how we live our lives.
As stated above, neuroplasticity can work for or against you. While the natural process of aging more or less handles the “working against you” side of that equation, it is completely within our abilities to harness the power of neuroplasticity to maintain or improve overall brain health. Taking an active role in improving the health of the brain can help fortify the body from some of the most debilitating chronic illnesses we face — the likes of Alzheimer’s, dementia, Parkinson’s, and multiple sclerosis. Fortunately, science has shined a light on numerous factors that have the potential to mitigate the effects of aging and improve overall brain health. To that end, I wanted to highlight six of the most effective ways you can maximize your brain’s potential.
Alzheimer’s disease, now affecting about 5 ½ million Americans, is a disease for which we have no meaningful treatment whatsoever. That said, it certainly makes sense to look at various factors that contribute to the risk for this disease. Continue reading
There is certainly a lot of discussion these days about the ketogenic diet, especially as it relates to brain function. I thought it would be instructive to review one of the most important, and early, research studies in this area, as it reveals several very important findings that are worthy of attention.
The study, Effects of beta-hydroxybutyrate on cognition in memory-impaired adults, dates back to 2003. Why this is relevant with respect to the ketogenic diet is because beta-hydroxybutyrate is one of the ketones produced when somebody is in ketosis. The ketogenic diet is one that is aggressive in terms lowering dietary carbohydrate intake while increasing dietary fats. The production of ketones is amplified in people who supplement with things like coconut oil or MCT oil. Continue reading
Despite countless hundreds of millions of dollars dedicated to seeking out a meaningful treatment for Alzheimer’s disease, as of the time of this writing the pharmaceutical promise of dealing with this epidemic remains unfulfilled.
So, if there is no meaningful treatment, it would seem sensible to focus on how Alzheimer’s disease and other forms of dementia could be prevented in the first place.
One of the most common questions I am asked, both when I am lecturing as well as on social media, focuses on the length of time it takes to change a person’s gut bacteria after dietary changes are made. Many would assume that these changes, which represent an adaptation of the gut microbes to a new diet, might take weeks or months. No doubt, people are anxious to know the answer to this question as they are becoming more and more aware of the critically important role of our gut microbes in determining our general health, weight, and risk for diseases including diabetes, arthritis, coronary artery disease, and even cancer.
In a recent study authored by Harvard researcher Lawrence David, the diets of six males and four females between the ages of 21 and 33 were manipulated in various ways. The subjects maintained a specific change in their diets for four days and assessments of their gut bacteria were made while on a new diet for six days thereafter. Continue reading
Dr. Martin Blaser, author of the book Missing Microbes, recently penned a thought-provoking editorial in the journal Science, titled, “Antibiotic use and its consequences for the normal microbiome“.
Dr. Blaser begins by confirming the critical role that antibiotics play in modern medicine. He then reiterates the words of Nobel laureate Alexander Fleming, inventor of penicillin, who in 1945 warned of the potential negative consequences of antibiotics, including the development of antibiotic-resistant organisms.
He then goes on to review how, shortly after their introduction for widespread use in humans, farmers discovered that treating livestock with antibiotics dramatically enhanced their growth. This discovery fostered the widespread use of antibiotics in the livestock industry, which has only persisted and grown over the last six decades. But beyond the historical significance of this discovery, the report calls attention to the fact that antibiotics are associated with important metabolic changes. This finding was a central idea elucidated in Dr. Blaser’s book, wherein he linked current antibiotic mismanagement to the global, ever-increasing rates of obesity. Continue reading