The Science

Our most well-respected scientific research validates the time-honored understanding that by far and away the most powerful factors affecting health and longevity are modifiable choices including the foods we eat and other aspects of lifestyle. So let’s move forward and explore this empowering information.

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Expression of Nrf2 in Neurodegenerative Diseases

Journal of Neuropathology and Experimental Neurology • January 1, 2007

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson’s Disease

Parkinson’s Disease • January 3, 2011

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

Neuropharmacology • November 8, 2013

Cognitive dysfunction with aging and the role of inflammation

Therapeutic Advances in Chronic Disease • June 7, 2011

Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

PLOS One • August 5, 2014

Sulforaphane Treatment of Autism Spectrum Disorder (ASD)

September 2, 2014

Dietary carbohydrate and the progression of age-related macular degeneration: a prospective study from the Age-Related Eye Disease Study

American Journal of Clinical Nutrition • June 6, 2007

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

GASTROENTEROLOGY • April 19, 2011

Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

Behavioural Brain Research • July 24, 2006

Neuro-Inflammation Induced By Lipopolysaccharide Causes Cognitive Impairment Through Enhancement Of Beta-Amyloid Generation

Journal of Neuroinflammation • April 16, 2008

The gut-brain barrier in major depression: Intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression

Neuroendocrinology Letters • February 22, 2008

So depression is an inflammatory disease, but where does the inflammation come from?

BMC Medicine • September 12, 2013

The gut microbiota — masters of host development and physiology

Nature Reviews Microbiology • February 25, 2013

Chronic intestinal inflammation alters hippocampal neurogenesis

Journal of Neuroinflammation • April 3, 2015

Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease

Natural Medicine • March 21, 2015

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