FBPixel Endocannabinoid Signaling in Reward and Addiction - David Perlmutter M.D.

Science

Study Title
Endocannabinoid Signaling in Reward and Addiction
Publication
Nature Reviews Neuroscience
Author(s)

Loren H. Parsons and Yasmin L. Hurd

Abstract

Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such as palatable food, sexual activity and social interaction) and modulates the rewarding effects of addictive drugs. Pathological forms of natural and drug-induced reward are associated with dysregulated eCB signalling that may derive from pre-existing genetic factors or from prolonged drug exposure. Impaired eCB signalling contributes to dysregulated synaptic plasticity, increased stress responsivity, negative emotional states and cravings that propel addiction. Understanding the contributions of eCB disruptions to behavioral and physiological traits provides insight into the eCB influence on addiction vulnerability.

Date
September 16, 2015
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Related Topics

AddictionRewardEpigeneticsNeuroplasticity

Dr. David Perlmutter is on the cutting edge of innovative medicine that looks at all lifestyle influences on health and illness.

Andrew Weil, MD