Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?


British Journal of Clinical Pharmacology


L. de Graaf, A. H. P. M. Brouwers & W. L. Diemont


Aims and methods: To describe patients with decreased libido during use of a HMG-CoA-reductase-inhibitor, and to discuss causality and pharmacological hypotheses for this association by analysis of the adverse drug reactions (ADR) database of the Netherlands Pharmacovigilance Centre Lareb.

Results: Eight patients were identified as having decreased libido during use of statins. In two of these cases testosterone levels were determined and appeared to be decreased.

Conclusion: Decreased libido is a probable adverse drug reaction of HMG-CoA-reductase-inhibitors and is reversible. The ADR may be caused by low serum testosterone levels, mainly due to intracellular cholesterol depletion.


February 5, 2004

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