FBPixel Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer - David Perlmutter M.D.

Science

Study Title
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Publication
Nature
Author(s)

Maria G Dominguez-Bello, Kassandra M De Jesus-Laboy, Nan Shen, Laura M Cox, Amnon Amir, Antonio Gonzalez, Nicholas A Bokulich, Se Jin Song, Marina Hoashi, Juana I Rivera-Vinas, Keimari Mendez, Rob Knight & Jose C Clemente

Abstract

Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria—which were underrepresented in unexposed C-section–delivered infants—and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section–delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section–delivered babies.

Date
February 1, 2016
View study

Share This

Related Topics

MicrobiomePregnancy

Dr. David Perlmutter is on the cutting edge of innovative medicine that looks at all lifestyle influences on health and illness.

Andrew Weil, MD