FBPixel APOE4 - David Perlmutter M.D.

APOE4

How to Lower Risk for Brain Amyloid

It is well-documented that the accumulation of the beta-amyloid protein in the brain is correlated with Alzheimer's disease. Ongoing research seeks to understand how, and at what stage of Alzheimer's, beta-a...

Implications of the “Alzheimer’s Gene” in Children

The development of highly accurate and widely available genome sequencing technology has put us at a crossroads. Now, more than ever, the divergent views of nature versus nurture confront consumers wishing t...

APOE effects on cognition from childhood to adolescence

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer’s Disease Risk Reduction and Early Intervention

Herpes simplex virus type 1 and Alzheimer’s disease: possible mechanisms and signposts

Taking Control of the “Alzheimer’s Gene”

Alzheimer’s disease, now affecting about 5 ½ million Americans, is a disease for which we have no meaningful treatment whatsoever. That said, it certainly makes sense to look at various factors that contribu...

Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation

Ketosis and Memory in Cognitively-Impaired Adults

There is certainly a lot of discussion these days about the ketogenic diet, especially as it relates to brain function. I thought it would be instructive to review one of the most important, and early, resea...

Ketone bodies as a therapeutic for Alzheimer’s disease