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Inflammation and Cellular Aging

One topic that’s certainly moved to center stage as of late is immunity. For obvious reasons there is great interest in exploring what we can do to enhance our immune functionality. The key idea, as it relates to functionality, is the notion of balance. While a robust immune system seems like it would be an ideal goal, we now know that excessive immune function may actually prove threatening. Such is the case with the so-called “cytokine storm.” Cytokines are chemical messengers that are involved in regulating immune function. When overproduced, as may occur in COVID-19 infection, cytokines can amplify inflammation with all its attendant destructive manifestations.

Regulation and balance of the immune system deteriorate with aging. So as we age we become more susceptible to inflammation, both acutely as with the cytokine storm, as well as chronically, in disease states like Alzheimer’s, Parkinson’s, coronary heart disease, diabetes, and various other chronic degenerative conditions. Continue reading

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Treating COVID-19 with Vitamin D

Over the past several months I have been writing and broadcasting about the potential role of vitamin D as it relates to COVID-19. Understanding the multiple roles that vitamin D plays in regulating immunity really supports the level of interest that we are seeing in the scientific community at a time when so many ideas are being vetted.

By and large, effectiveness of any intervention is looked at in terms of either prevention of a problem or its actual treatment. And while there is a fairly robust body of literature accumulating that clearly shows higher risk for the disease as well as worse outcome associated with low levels of vitamin D, actually using vitamin D as a treatment for existing disease hasn’t really been extensively studied. Continue reading

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The Empowering Neurologist – David Perlmutter, M.D., and Drs. Danilo Bzdok and Robin Dunbar


One of the most pervasive recommendations these days centers on the benefits related to socially distancing ourselves from others. And while this may be a meaningful recommendation, an unfortunate consequence seems to be increasing social isolation.

Social isolation begets loneliness, and loneliness is pervasive in modern society. Research reveals profound relationships between levels of loneliness and risk for various health conditions. Important for our current experience with COVID-19 is the relationship between social isolation and immune dysfunction. Continue reading

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3 Ways to Care for Your Brain in a Pandemic

By Dr. Austin Perlmutter

In the wake of the global spread of the 2019 coronavirus (COVID-19), many of us have started to think more carefully about our health. How can we reduce our risk of infection and of infecting others? How can we improve our immune function? What might the virus do to our lungs, heart and blood vessels? But while these questions are very important, it’s also critical to consider how a pandemic affects our brains and how to guard them against this damage. Specifically, we need to be considering strategies to protect our mental and cognitive health.

We’ve long known that mental health suffers in periods of high stress. So it’s no surprise that the current pandemic has been linked to a spike in feelings of anxiety and depression. A troubling May 2020 survey reported that over 34% of Americans are now experiencing these symptoms. This comes at a time when the world is already experiencing an epidemic of mental illness. Continue reading