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Depression

The gut-brain barrier in major depression: Intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression
April 20, 2015

The gut-brain barrier in major depression: Intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression

Depression, The Microbiome & Leaky Gut
February 22, 2015

Depression, The Microbiome & Leaky Gut

One of the things I explore in depth in Brain Maker is the notion that even depression is now considered an inflammatory disorder. We now understand that inflammatory markers, the same that we see elevated i...
Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers
November 5, 2014

Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers

Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects
November 5, 2014

Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model
November 4, 2014

Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model

Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat
October 19, 2014

Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat

How Zyprexa Alters Your Metabolism
October 19, 2014

How Zyprexa Alters Your Metabolism

Zyprexa, is an incredibly popular psychiatric medication manufactured by Eli Lilly. Yet, although Zyprexa was originally developed for the treatment of schizophrenia and bipolar disorder, it has now gained w...
New Study Shows How Gut Bacteria Affect How You See the World
July 8, 2014

New Study Shows How Gut Bacteria Affect How You See the World

In a challenge to our narcissism, a new report in the journal Gastroenterology, reveals that our gut bacteria may actually be playing an important role in our emotional responses. Dr. Kirsten Tillisch, assoc...
Five Ways to Fight Depression (Without Drugs!)
April 28, 2014

Five Ways to Fight Depression (Without Drugs!)

By: Austin Perlmutter, MD, Medical Student, Miller School of Medicine Depression is the leading cause of disability in young Americans, a significant burden for those affected and those around them. With so...
How to Choose Happiness: The Neurochemical Basis
April 25, 2014

How to Choose Happiness: The Neurochemical Basis

By: Austin Perlmutter, MD, Medical Student, Miller School of Medicine Happiness is tough to find. We seek it out in our accomplishments, relationships, experiences, and our possessions. When this doesn’t pa...
Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight
April 23, 2014

Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight