Is high fructose corn syrup (HFCS) really as much of a problem as people would like us to believe? And in fact, what about fructose in general? After all, the actual biochemistry of fructose metabolism does not activate insulin, and therefore it might not be as big of an issue in terms of representing a health threat compared to other sugars, like glucose or dextrose. Right?
Well, let’s dig into the science a little bit and see what we can learn. In a new study published in the Journal of Hepatology, researchers wanted to explore how fructose, sucrose (common table sugar, which is made up of 50% glucose and 50% fructose), or glucose affected the body in terms of some fairly important parameters like the generation of fat in the liver.
The study evaluated the effects of these sugars in 94 healthy young men over a seven-week period. The subjects consumed, on a daily basis, drinks containing fructose, sucrose, or glucose, 80g per day, or a drink that did not contain sugar. Continue reading
Over the past several years a mechanistic concept has arisen that seeks to explain the pathogenesis of Alzheimer’s disease. This has been called the bioenergetic theory. Basically, it describes a situation in which the highly energy demanding cells of the brain are somehow compromised in their ability to use fuel. Make no mistake about it, brain cells require an incredible amount of energy to perform their function. In the resting state, the brain, which typically represents only 2 to 5% of total body weight, consumes up to 25% of calories burned.
The brain’s primary fuel is glucose. And one of the hallmarks of Alzheimer’s disease is a progressive failure of the brain’s ability to use this source of fuel, basically a situation in which brain cells are not able to utilize glucose for energy. In fact, specialized PET scanning of the brain can visualize signature areas of the brain that are less functional in terms of glucose utilization that correlate with Alzheimer’s disease. Continue reading
One very popular variation of outright fasting is what is called time-restricted feeding (TRF). In both humans and laboratory animals, TRF refers the consumption of food only during a specific period of time each 24 hours. We know that this is certainly in contrast to the common way that people eat, meaning at least three meals a day with lots of snacks before, between, and after meals.
As it turns out, there appears to be quite a few health advantages to restricting the period of time that we eat during the day. Research has revealed, for example, how TRF positively affects a variety of cardiometabolic risk factors including blood sugar, and even the expression of our genes. Continue reading
By Austin Perlmutter, MD
We’re always taught to set a good example for our children, but what if your decision to exercise influenced the health of your future offspring? A recently published study in the journal Diabetes looked at this very question. Continue reading
It’s fairly common knowledge these days that there are some really important health benefits associated with consuming olive oil. No doubt, one of the reasons that the Mediterranean diet turns out to be so healthful is because it is rich in olives and olive oil. And this may explain why following the Mediterranean diet is associated with significant risk reduction for things like breast cancer, heart disease, diabetes, and even dementia.
But it’s been a bit challenging to try to delineate specifically what it is about olive oil that makes it so special as it relates to health. There are multiple chemicals found in olive oil that are bioactive in a positive sense, and new research has identified yet another chemical and mechanism that may explain why olive oil is so good for us. Continue reading
Go to the mall. See a movie. Look around next time you’re in an airport. What you’ll see is the confirmation of all the statistics that we’re hearing so much about these days related to the ever-increasing prevalence of obesity. It’s everywhere and it’s affecting most of us.
Books, online information, infomercials, daytime T.V., and even nightly news programs are constantly hammering us with the scary news that relates increasing abdominal girth to just about every bad medical condition you don’t want to get. At the same time, these same resources offer up some new trendy solution to the obesity epidemic daily, often in the form of some new and exotic dietary supplement.
Truth is, losing weight doesn’t happen when you give in and buy the latest pill. Weight loss happens when the body shifts from storing fat to burning fat. It is that simple, and far and away how we signal our metabolism to make this fundamental shift depends on what we choose to eat. Continue reading