Over the past several years a mechanistic concept has arisen that seeks to explain the pathogenesis of Alzheimer’s disease. This has been called the bioenergetic theory. Basically, it describes a situation in which the highly energy demanding cells of the brain are somehow compromised in their ability to use fuel. Make no mistake about it, brain cells require an incredible amount of energy to perform their function. In the resting state, the brain, which typically represents only 2 to 5% of total body weight, consumes up to 25% of calories burned.
The brain’s primary fuel is glucose. And one of the hallmarks of Alzheimer’s disease is a progressive failure of the brain’s ability to use this source of fuel, basically a situation in which brain cells are not able to utilize glucose for energy. In fact, specialized PET scanning of the brain can visualize signature areas of the brain that are less functional in terms of glucose utilization that correlate with Alzheimer’s disease. Continue reading
By the Dr. Perlmutter Team
The ketogenic diet appears often in content I share as it offers a host of health benefits for conditions including Alzheimer’s disease, epilepsy, Parkinson’s disease, diabetes, and more. That list may now include mental disorders. As I recently discussed with Dr. Uma Naidoo, nutritional psychiatry is centered on how food affects mental health. While dietary interventions are known to serve multiple preventive and therapeutic roles in human health, it is exciting that there is a burgeoning field focusing specifically on how nutrition impacts mental disorders, especially in these challenging times.
These days so much is being written about the health benefits of lifestyle and nutrition strategies that produce ketosis. Indeed, actually treating certain conditions is now a fair-game discussion because of the robust scientific support being generated from institutions around the world.
I have previously presented information detailing the therapeutic benefit of a ketogenic lifestyle for issues like diabetes (both types 1 and 2), dementia, metabolic syndrome, and obesity. To be sure, there’s some outstanding work being done that demonstrates the effectiveness of a ketogenic program in Parkinson’s disease (PD). And one of the pioneers in studying the ketogenic diet in PD is Dr. Matthew Phillips, a neurologist in New Zealand who we’ve previously featured on The Empowering Neurologist. More recently, I had the opportunity to co-author, along with Dr. Phillips, a book chapter focused on the use of a ketogenic diet as an actual therapeutic intervention for Parkinson’s disease. Continue reading
At 57 years-old and 460lbs, my father passed away. Watching this happen at 40, I knew I needed to turn my life around. Grain Brain, and a ketogenic lifestyle, did that for me.
I went from 360 lbs. to ~250 lbs. in a couple years. I started with a modified keto diet, but as I saw results I continued to improve over a 3-year period to reach the optimal keto diet I am currently on, which is low-fat, high-protein, and extremely low-carb diet. As a lifestyle change, I have combined this with intense strength training. I feel 18 again, and can keep up with anyone else in the gym without needing carbs. I recover exceptionally well and my joints feel great. Best of all, my body is dropping fat fast. I’m almost in a size 34 jean now at 258 lbs.
I eat very clean, organic protein, lots of spinach, broccoli, asparagus, etc. I enjoy grass-fed beef, properly raised and fed chicken, and have been adding more fish to my diet as well. Never eat any wheat/gluten, ever.
The science surrounding the ketogenic diet expands day by day. In today’s video I will explore some of the science that shows a relationship between the ketogenic diet and increased brain glutathione levels, and explain why that matters for brain health. The full study can be found here. Continue reading