By: Austin Perlmutter, MD, Medical Student, Miller School of Medicine
As research on the microbiome flourishes, we continue to find evidence for the role of probiotics in optimizing our health. Most recently, an analysis published in the journal Hypertension examines the effect of probiotic supplementation on our blood pressure. Considering that two thirds of Americans are pre-hypertensive or fully hypertensive, this data may prove extremely significant
Over the last several years, we’ve started investigations on how probiotics affect everything from brain health to acne. Though this is a relatively new field of academic concentration, the interplay between bacteria and human has been increasingly illuminating. One area of focus examines changes in blood pressure with probiotic administration. Several studies have observed positive interactions, but this meta-analysis is the first to cross-analyze and synthesize the available information. Continue reading
Bowel wall permeability, more commonly described these days as “leaky gut,” is now front and center in the news, and is well known as a cause of a large number of common disease entities. The intestinal barrier that separates the luminal contents from the systemic circulation is, incredibly, only one cell thick! This extends from the esophagus to the anus. That means that we are dependent on a one cell layer, as well as the connections between these single cells, to carefully screen what is taken in and what is excluded.
The integrity of the gut lining can be compromised by any number of influences including antibiotics, stress, various medications, including nonsteroidal anti-inflammatory drugs, as well as steroids, harmful bacteria, glycated proteins, and even exposure to gluten. When the permeability of the gut lining is increased, it sets the stage for a dramatic increase in inflammation and compromises our immune system’s ability to determine self versus non-self. The latter is a hallmark of autoimmune diseases including lupus, diabetes type I, psoriasis, rheumatoid arthritis, and so many more of the common maladies of our modern world. Continue reading