By: The Dr. Perlmutter Team
One of the most exciting developments in lifestyle science over the last decade has been the sharpening focus on the central role that our resident microbes (bacteria) play in regulating overall health. These microbes, together with their genetic material and metabolic byproducts make up what is collectively known as the microbiome. It is becoming readily apparent that the trillions of microbes living on and within us play a fundamental role in almost all of the systems of the body. Even as recently as 10-20 years ago, we did not understand the extent to which the gut microbiome can influence a person’s mood, regulate appetite, produce essential vitamins, regulate the immune system, and influence systemic inflammation.
There is even evidence to suggest that the microbiome affects us on such a fundamental level that it can regulate the expression of our DNA! Continue reading
As we all know, allergic diseases, particularly in childhood, are becoming more and more common. It’s not just that we are becoming more aware of allergic diseases, think of the frequent announcements on airplanes about peanut allergies, or food allergy questions by the waiter at dinner. No, the reality of the situation is that, by and large, allergies are simply far more common than they used to be.
So, why is this happening? Let’s take a step back and recognize that the intestines, oddly enough, actually play an important role in determining our immune responsiveness. Specifically, we now understand that the gut lining itself actually plays an important role in regulating immune function. Permeability, or leakiness, of the gut lining is associated with alteration in immune function as well as changes to the set point of inflammation. Continue reading
It is very exciting to see the incredible increase in scientific research being released that relates gut issues to various health problems elsewhere in the body. The research that explores this relationship in terms of autoimmune conditions is particularly interesting, not just because it links gut-related problems to changes in immune balance, but in terms of how this new understanding might open the door for new treatments for these challenging conditions.
This week, Columbia University announced a “breakthrough” in our understanding of how gluten relates to health issues. Their findings, published in the journal Gut, revealed that the complaints gluten-sensitive people (those with non-celiac gluten sensitivity) experience are a consequence of a disruption of the gut lining – what has come to be called “leaky gut.”
We hear more and more concern about the impact glyphosate, the lead ingredient in RoundUp, is having on the microbiome. While correlation does not mean causation, and while some of the science on this issue is still evolving, what we can say is that it does change the balance of the bacteria in the microbiome, setting the stage for leaky gut and autoimmune disease.
We talk a lot about leaky gut and the complications that result from this condition. However, a similar problem can happen in the brain. The blood brain barrier that keeps the brain as a sanctuary away from things like bacterial components and damaging chemicals can also be breached – and some of the same mechanisms that give rise to a leaky gut can create a leaky brain.
Learn more in my most recent video, as well as in my new book, Brain Maker.