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Uric Acid – A Pivotal Player in Metabolic Diseases

We are now at the dawn of a new age as it relates to our understanding of important chronic diseases like metabolic syndrome, hypertension, type 2 diabetes, obesity, and non-alcoholic fatty liver disease. It is now clear that uric acid, previously just considered to be a waste product of metabolism, is playing a central role mechanistically in these pervasive problems.

In a recent review published in the European Journal of Internal Medicine entitled Uric Acid in metabolic syndrome: From an innocent bystander to a central player, scientists explored how uric acid plays a fundamental role, signaling the body to make and store fat, increase its blood pressure, and enhance glucose production. We all carry this type of physiology as a legacy of our primate ancestors for whom making and storing fat, for example, proved to be a survival mechanism during times of food scarcity. Continue reading

metformin_aging_exercise_diabetes

An Anti-Aging Medicine?

I recently had the unique opportunity to serve as an advisor for the development of the next XPRIZE. Many of you may have heard of the XPRIZE for space, and this new prize is, to a degree, similar. The new XPRIZE is being developed to help spur research in the field of longevity. As such, unlike the space prize, in which a finite goal could be easily established, developing a goal that would serve as a surrogate for longevity is more of a challenge. Nonetheless, it is a work in progress.

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