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Benefits of Probiotics for your Mood, Gut, and Immune System

By: The Dr. Perlmutter Team

One of the most exciting developments in lifestyle science over the last decade has been the sharpening focus on the central role that our resident microbes (bacteria) play in regulating overall health. These microbes, together with their genetic material and metabolic byproducts make up what is collectively known as the microbiome. It is becoming readily apparent that the trillions of microbes living on and within us play a fundamental role in almost all of the systems of the body. Even as recently as 10-20 years ago, we did not understand the extent to which the gut microbiome can influence a person’s mood, regulate appetite, produce essential vitamins, regulate the immune system, and influence systemic inflammation.

There is even evidence to suggest that the microbiome affects us on such a fundamental level that it can regulate the expression of our DNA! Continue reading

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9+ Foods to Improve Brain Health and Memory

By: The Dr. Perlmutter Team

As we’ve stated before, one of the most fascinating things about the human brain is that neuroplasticity, the process by which the brain undergoes changes in response to internal and external stimuli, affords us a great deal of control in determining the overall health of our brain. While there are many lifestyle changes one can make to improve overall brain health, studies have shown that dietary factors can have a significant impact. Choosing which foods you use to fuel your body goes far beyond counting calories; the macronutrients—fats, proteins, and carbohydrates—you emphasize in shaping your diet can have major repercussions for brain health. There is evidence to suggest that individuals who consume a diet high in carbohydrates have an 89% increased risk of developing dementia, while people who consume a diet high in healthy fats actually reduce their risk by 44%. Ensuring that the foods you consume are high in antioxidants, rich in healthy fats, low in carbohydrates, and powerfully anti-inflammatory can go a long way towards optimizing brain health and boosting memory and cognition.

Foods to Improve Brain Health and Memory

Generally speaking, we recommend a diet that is higher in fat and fiber, low in carbs, and rich in gut-healthy probiotics. To that end, please read on for some suggestions on specific foods around which to build a brain-boosting diet!

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Probiotics for Mental Health

Recently, I was interviewed by the magazine Men’s Health to discuss the positive benefits of probiotics and their potential applications for improving mental health and conditions like depression. I wanted to dive a bit deeper into the thoughts I shared in the article, and go over some key takeaways. Read the article and let me know what you think!

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The Empowering Neurologist – David Perlmutter, MD and Dr. Whitney Bowe


I am hopeful that, at this stage of the game, it will not come as a total surprise that even the health and appearance of our skin is affected by microbes and the microbiome.

Many of us grew up at a time when bacteria were universally considered to be detrimental and and therefore were the targets of therapies to treat specific conditions. Acne, for example, was considered to be a disease caused by the action of a bad bacterium which was then targeted with topical and oral antibiotics, as well as various other skin sanitizing techniques. Unfortunately, to a significant degree, this mentality remains pervasive. Continue reading

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The Importance of Fish Oil and Probiotics in Pregnancy

Food allergies, and a specific skin condition called eczema, are rapidly increasing in the youth population. Now, in what may be the largest study of its kind ever performed, researchers are studying a woman’s diet during pregnancy, as well as duration of breast-feeding post-birth, to assess a child’s susceptibility to allergies, as well as risk for conditions like eczema and autoimmune disorders. British investigators, evaluating over 1.5 million people, have come up with some very compelling information.

The research is what’s called a meta-analysis, meaning that it is review of previous studies (over 400 in this case) involving over 1.5 million people, and dating as far back as 1946. The researchers discovered that there was a weak, but nonetheless demonstrable, relationship between breast-feeding and reduced risk of eczema during infancy, as well as reduced risk for type I diabetes. In addition, probiotics seemed to reduce the risk of allergic reactions to cow’s milk.

The data, however, was much more supportive of the relationship between taking a probiotic supplement while 36 – 38 weeks pregnant, and during the first 3 to 6 months of breast-feeding, and risk for childhood eczema. In fact, in those women taking probiotics, risk for eczema in their child was reduced by 22%. The scientist noted that most of the probiotics contained a bacterium called Lactobacillus rhamnosus. Continue reading

Mike L.

Brain Maker has completely changed my life.

My 7-yr-old daughter has been battling the hair-pulling disorder (Trichotilomania) since she was born. We’ve been to many therapists but none were not able to help. Lately it had been a little more seasonal, worse in the summer than other times of year. We were wondering if it was the extra sunlight? Less sleep? Missing structure at school? Sick of being home? The list could go on and on. But after reading about how antibiotics can completely change one’s mood, it clicked!

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Probiotics: A New Treatment for Alzheimer’s?

In Brain Maker, we looked at the relationship between the health of the gut and that of the brain, particularly as it relates to how the gut is the origin of inflammation, a cause of Alzheimer’s disease, an inflammatory disorder. With that in mind, shouldn’t we be able to improve our gut health as a way to treat Alzheimer’s? Well, the latest science has something to say about that. Continue reading

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Why Supplementing with Prebiotic Fiber Makes Sense

While there has been so much attention given in recent years to the importance of probiotics across a wide spectrum of important aspects of human physiology, we are just beginning to see an expansion of the medical literature clarifying the importance of prebiotic fiber as it relates to health.

Prebiotic fiber is a type of carbohydrate that we as humans do not digest. That said, our gut bacteria thrive on prebiotic fiber, as it allows them to reproduce, and enhances their ability to make various products that are so important for our health.

Much of the work on prebiotic fiber has been done using the animal model, typically mice, in which administration of prebiotic fiber has been shown to have dramatic and positive effects, upon the gut bacteria. Beyond that, positive metabolic effects are seen as well.  Continue reading