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The Empowering Neurologist – David Perlmutter M.D., and Dr. David Sinclair

Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals,” changes in the function of our mitochondria, and so many others.

Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state. Continue reading

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The Empowering Neurologist – David Perlmutter M.D., and Wim Hof

Holy Toledo! Did yours truly just have an amazing interview? You bet. I spoke with Wim Hof, a.k.a. “The Iceman.” Wim holds 26 world records for his feats of endurance and exposure to cold―such as climbing Mount Kilimanjaro wearing only shorts and shoes, running a barefoot half-marathon in the Arctic Circle, and standing in an ice-filled container for more than 112 minutes. On March 16, 2000, Hof set the Guinness World Record for farthest swim under ice, with a distance of 57.5 meters (188.6 ft).

Having been taught by the majestic natural power of the cold exposure coupled with a unique breathing technique, Wim is on a mission to share his discoveries with the world. Continue reading

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The Empowering Neurologist – David Perlmutter, M.D. and Tana Amen

It has been said that “into each life some rain must fall.”

That’s pretty much a given, for most of us.

The challenge becomes how we let these experiences inform us moving forward. Tana Amen, author of the new book The Relentless Courage of a Scared Child, takes us through how her terrifying childhood of abandonment and abuse, numerous battles with cancer and depression, and a never-ending fight to be valued for more than her outward appearance conspired to rob her of a voice—and the healthy future she deserved. She then reveals how she found her voice, safety, and developed habits that she will share with you today to be mentally and physically strong as we enter 2021.

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Long-Haul COVID – What You Need to Know Today

The term “long-haul COVID” has now entered our lexicon in relationship to this infectious disease. Unlike so many other infectious events, it looks like, in many people, COVID-19 is not monophasic. This means that a significant number of individuals have persistent symptoms for extended periods of time. This experience may now be affecting millions of people globally following their supposed “recovery.”

In fact, the NIH in December 2020 sponsored a meeting to call attention to this specific problem because of its global extent. Indeed, the long-term consequences of COVID-19 are now being described as a “second health crisis,” globally.

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The Empowering Neurologist – David Perlmutter, M.D. and Dr. Dale Bredesen


It’s exciting to watch new developments in medicine, especially when new treatments for diseases are developed. Unfortunately, there is no treatment that has any merit for Alzheimer’s disease. Think of it, this disease that affects close to 5.8 million Americans is a disease for which we have no meaningful treatment whatsoever.

As many of you know, Dr. Dale Bredesen has pioneered a novel approach to Alzheimer’s disease. Rather than offering up a single treatment, he has created a multi-pronged program that is proving successful in reversing this disease. Yes, I’ll repeat, this program has reversed Alzheimer’s disease. Continue reading

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The Empowering Neurologist – David Perlmutter, M.D., and Dr. Uma Naidoo


What an exciting and important presentation we have for you today. For many years we have been providing information focused on the pivotal role of nutritional choices as they relate to the brain, mostly in the context of neurodegenerative conditions like Alzheimer’s disease. Today, we’re going to explore how our nutritional choices actually impact us from a mood perspective with our very special guest, Dr. Uma Naidoo. Let me tell you a bit more about her.

Michelin-starred chef David Bouley described Dr. Uma Naidoo as the world’s first “triple threat” in the food as medicine space: She is a Harvard-trained psychiatrist, professional chef who graduated with her culinary schools’ most coveted award, and a nutrition specialist. Her niche work is in Nutritional Psychiatry and she is regarded both nationally and internationally as a medical pioneer in this field.

In her role as a Clinical Scientist, Dr. Naidoo founded and directs the first hospital-based clinical service in Nutritional Psychiatry in the USA. She is the Director of Nutritional and Lifestyle Psychiatry at Massachusetts General Hospital (MGH) & Director of Nutritional Psychiatry at the Massachusetts General Hospital Academy while serving on the faculty at Harvard Medical School.

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The Empowering Neurologist – David Perlmutter, M.D. and Dr. Matthew Phillips


Today on The Empowering Neurologist I had the pleasure of again spending time with Dr. Matthew Phillips. He’s been on the program in the past discussing the effectiveness of the ketogenic diet in Parkinson’s disease.  

Today he explores the notion of fasting, and reveals how powerful a therapy this may represent as it relates to both keeping the brain healthy as well as in the treatment of existing disease. Continue reading

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The Empowering Neurologist – David Perlmutter, M.D., and Drs. Danilo Bzdok and Robin Dunbar


One of the most pervasive recommendations these days centers on the benefits related to socially distancing ourselves from others. And while this may be a meaningful recommendation, an unfortunate consequence seems to be increasing social isolation.

Social isolation begets loneliness, and loneliness is pervasive in modern society. Research reveals profound relationships between levels of loneliness and risk for various health conditions. Important for our current experience with COVID-19 is the relationship between social isolation and immune dysfunction. Continue reading