We are now at the dawn of a new age as it relates to our understanding of important chronic diseases like metabolic syndrome, hypertension, type 2 diabetes, obesity, and non-alcoholic fatty liver disease. It is now clear that uric acid, previously just considered to be a waste product of metabolism, is playing a central role mechanistically in these pervasive problems.
In a recent review published in the European Journal of Internal Medicine entitled Uric Acid in metabolic syndrome: From an innocent bystander to a central player, scientists explored how uric acid plays a fundamental role, signaling the body to make and store fat, increase its blood pressure, and enhance glucose production. We all carry this type of physiology as a legacy of our primate ancestors for whom making and storing fat, for example, proved to be a survival mechanism during times of food scarcity. Continue reading