Category: Science

antibiotics_mitochondria

Important News About Antibiotics

According to the Centers for Disease Control and Prevention (CDC), more than a quarter billion courses of antibiotics are dispensed to outpatients in America each year. That means that five out of every six people, on average, are getting a prescription for an antibiotic. The CDC tells us:

At least 30% of antibiotics prescribed in the outpatient setting are unnecessary, meaning that no antibiotic was needed at all.

There are many reasons for concern as it relates to the overuse and inappropriate use of antibiotics. Creating antibiotic-resistant organisms is a major global issue. In addition, new research indicates that antibiotic exposure may significantly increase the risk for obesity, as well as type II diabetes.

An important premise that we as healthcare practitioners have subscribed to is one that indicates that antibiotics kill bacteria but cause no harm to our body’s cells. But new research is challenging this idea. In a recent report appearing in the journal Translational Medicineresearchers revealed that some of our most commonly used antibiotics are actually toxic to mitochondria, the small bacteria-like particles that live within each of our bodies. Exposure to antibiotics of various types has now been demonstrated to damage mitochondria and at the same time increase the formation of toxic free radicals that can further damage tissue, including protein, fat, and DNA.

Interestingly, in the study, the detrimental effects of the antibiotics seemed to be offset when the animals were treated with a nutritional supplement, N-acetyl-L-cysteine, (NAC). NAC was found to dramatically mitigate damage to mitochondria with the authors concluding that the use of NAC might help us achieve, “the goal of improving the safety of antibiotic treatment in people.”

This is very important information from two perspectives. First, the potential damage to our mitochondria is yet another reason to be as judicious as possible in terms of using antibiotics. Second, this newly discovered, potentially detrimental, effect of antibiotics might well be prevented by the use of a simple nutritional supplement.

  • TechnoTriticale

    On the Warburg/Seyfried metabolic theory, this would also seem to have serious implications for cancer risk. There might be some epidemiological data to be turned up on this.

    In addition to NAC, I suspect there are other supplements that might support mito function during unavoidable courses of antibiotics.

    Thanks for making the paper available, as it otherwise appears to be pay-walled.

  • Roxie

    I have been suffering antibiotic resistant C-Diff since 2011, I was given antibiotics during a surgery. Never told, common practice. Your article on vitamin D, could that help when you absoutly must take antibiotics to help prevent C-Diff?

    • Lynn Dell

      I would be doing the following: eating lots of fermented foods, taking probiotic supplements, and prebiotic fiber. I would try to avoid sugars and starches as much as possible, and don’t ask me why for the last, I would start and end each day by drinking a shot of Bragg’s cider vinegar. If I were on antibiotics, I would take the probiotic supplements halfway in between the antibiotics. Mitochondria seem to benefit from coenzyme q as well.

      • Sue Detrick

        Some good suggestions, Lynn Dell. Just a word of caution about fermented foods and ACV …. people with certain mast cell conditions or histamine deregulation conditions can become very ill from consuming fermented foods and things like ACV. These conditions mimic or are key factors of other health problems.
        Mast cell and histamine deregulation disorders are becoming more and more prevalent among the general population due to long term cumulative exposure to various types of toxins that are consumed and taken in through other means including the environment.
        Although fermented foods were always regarded as the best healthy foods one could consume… they still are for some but no longer for everyone.

        • Lynn Dell

          Good to mention. We suspect my husband has these issues, and we had been trying foods higher in diamine oxide, quercitin, ect.. There are also many ways to detoxify, which I have yet to study.

          • Sue Detrick

            Lynn, people can have a deficiency or genetic mutation in DAO. If that is suspected, then genetic testing would be helpful to specify what the exact mutation is because it would take him down a different dietary path. I don’t know how far you are into your study but here are 2 very informative resources that I’d like to share in case you have not seen them. Good Luck!

            https://healinghistamine.com/

            http://suzycohen.com/articles/histamine_intolerance_dao_genes_hashimotos/

          • Lynn Dell

            Thanks. We noticed symptoms after he started on baby aspirin. After stopping the aspirin, we also tried to lower consumption of foods that had salicylates in them. Lots to sort out, thanks.

        • Joan

          Amen Sue. This is exactly what happened to me. I made myself much much sicker eating fermented foods and multi-strain probiotics as well as prebiotics. It took me almost a year and untold misery before I discovered this information about histamine disregulation.

        • Marley
          • AnnieLaurie Burke

            I am a great believer in high doses for vitamin C for any viral OR bacterial infection, or any abnormal stress conditions. I have used it on myself, and on both cats and dogs (that supposedly make their own, but not enough when they need it) in my animal rescue efforts. I could write a book on the excellent results. Never any side effects in me or the animals. And it’s hard to argue “placebo effect” with cats and dogs.

          • Jean

            Annie, what dosage would you give an 18 pound dog? She has a urinary tract infection that is being treated with antibiotics right now. How would you prevent her from getting this again if she were your dog? Thank you!

          • AnnieLaurie Burke

            I am not a veterinarian, so I can’t give medical advice, but I can tell you what I have found helpful. Since some might consider this off-topic for this newsletter, may I suggest you contact me through Facebook (same name)? Then, I can give you more detailed suggestions and a list of resources that may be helpful to you and your veterinarian in healing your pup.

          • Jean

            Annie, I am not on Facebook so I wouldn’t be able to contact you that way. Here is my email: jeanschl@wwt.net. Could you contact me that way? Thank you!!!!

          • Ottavia Zeffilini

            How do I post only this video on facebook,, when I share it posts the whole articule of Antibiotics which is good needed too but only want post this video> help

          • Roxie

            Start playing, put mouse over video, right click and copy URL or use this link: https://www.youtube.com/watch?v=W5Bgdqsorg0&feature=youtu.be

          • Ottavia Zeffilini

            Thanks Roxie for the info and glad you said or click this. I am kindergarden on computer, right click URL ?not even sure how do that but will try also for to learn. Live in remote area HI but I did find a new learn about computers class and will be going. Thanks again, Aloha

      • Roxie

        Thanks Lynn. From what I read on C-Diff, not to take probitics at this point. Staying away from sugars, really bad for the gut.

        • Pat Minnigh

          Then definitely not a good source for you! Look into the fecal transplant. Even if it is out of your own pocket, it would be worth it. You have suffered too long. God bless you!

    • Pat Minnigh

      We cured my Mom’s CDiff with a long and graduated course of Vincomyacin. She started out on a full dose for about 3-4 weeks then graduate down until you are every other day for about 4 weeks. It cleared up completely and we had tried everything before that!

      • Roxie

        I have lost hearing from it, was tested once a week for two weeks and dropped from normal to needing a hearing aid.

        • Pat Minnigh

          Then definitely not a good source for you! Look into the fecal transplant. Even if it is out of your own pocket, it would be worth it. You have suffered too long. God bless you!

          • Roxie

            That’s what I’m having done. Very high success rate

          • Pat Minnigh

            Please let us know how it goes! Praying that it’s very successful!

    • Ken Ferko

      Have you looked into stool replacement therapy? It’s relatively new, and has had tremendous success where conventional treatments have failed. Google it -it might be worth a try…

      • Roxie

        I am amazed on what FMT can all treat, I was scheduled for today, but there was a mix-up in the order. A study was done and 95% of people who had the transplant said their first choice if they got C-Diff again, would be the FMT. We are going to be hearing a lot more about this in the near future. Only wish insurance would cover it. Studies are being done for Parkinson’s, diabetes even losing weight from a thin donor!

      • Pat Minnigh

        Fecal transplant has been 90% effective. I think that is a great option if you don’t want to do the antibiotic regime. FYI, probiotics are always good and I would continue them even though the CDif is active. You need the good bugs in your gut. Eliminate sugars and grains, add Vit D, Calcium, CoQ10, a good anti- inflammatory like OPC and a good B Complex Along with a good multi-vitamin. I use Isotonic Delivery Vitamins and Suppliments that I get from Savvy Selections. Just some thoughts. I hope you find some relief!

        • Roxie

          From what I have read, probotics are not the way to go before a transplant. Sugars, grains, fiber has been eliminated. At this point can’t handle my meds, would really like to take D but nothing is staying down.

  • Susan

    Does it help to take NAC after a course in antibiotics, or is it necessary to take NAC at the same time as the antibiotics?

  • M Syed

    This may explain some of the increased risk of autism seen with antibiotic use..

  • Pat Minnigh

    I have Lyme’s and the only known treatment, at this point, is a long course of Doxycycline. I will take probiotics morning and night, but the other holistic treatments don’t go far enough. An suggestions?

    • Jean

      I had Lyme’s and was on 15 weeks (not a misprint) 15 weeks of Doxycycline and still had lymes. I was
      cured in 4 weeks with a natural cure that is well known in the Eau Claire WI area. Please contact Dr. Lindsley in Bloomer WI. He is teaching the protocol to may other natural practitioners also. Here is his address and phone number: 1565 195th Ave, Bloomer WI 54724 Ph: 715-568-5058. It is very possible he could send you a bottle. My body was shutting down. It took 4 western medicine doctors to diagnose the Lymes disease…our region is filled with it….give me a break!!! For us in Western Wisconsin we are no longer afraid of getting lymes disease because of Dr. Lindsley. I guarantee you will not regret getting in touch with him.

      • Pat Minnigh

        I will check that out! Thanks! My Lyme’s manifested itself as full body (not just peripheral) neuropathy. It has taken me a lot of PT along with Gabepenton and Lorezapam to be able to walk without a cane. If I go too late no without either of these drugs, my chest feels like it is squeezing all the breathe out of me! My heart is good. I have all of thise tests, to include a stress test.

        • Jean

          Pat, I’m so sorry to hear all you have gone through with this. Dr. Allan Lindsley helps many people get rid of all the negative effects of Lymes disease also. I never thought I would be the same again and was fully recovered just like he said…..in 4 weeks!!! I’m not sure where you live but it may be worth a visit to Bloomer, Wisconsin. This obviously is his specialty and we feel very lucky to have him. How gracious of him too to teach other natural health practitioners his protocol.

      • Rita Nystrom

        If you don’t mind sharing what is in his protocol?
        Thanks Jean

        • Jean

          Dr. Allan Lindsley is the “go to” practitioner here in Western WI for anyone with Lyme Disease, co-infections, no matter how severe your symptoms. I do not know what is in this, but I do know it is 100% natural. I took two teaspoons a day of this and just as he told me, a month later was back to my original good health. My body was shutting down….very, very scary. Most people here in the Eau Claire WI area know about Dr. Lindsley and his treatment of Lyme’s disease. Thank goodness he is teaching other natural practitioners his protocol as he for sure could never treat everyone. I hope this answers your question Rita.

  • AnnieLaurie Burke

    Many antibiotic prescriptions written for children are actually for the benefit of the parents — window dressing to reassure parents that the doc is “doing something”. But, that “something” does nothing for the cold, flu, or other viral infection the child has. This is nothing new — when I was a child (I am now 70), if any of us kids got a cold or flu, we were taken to the doc and got a shot (a USELESS shot) of penicillin. One would have hoped that, as medicine supposedly advanced,the practice of giving useless antibiotics would have stopped, o at least decreased. Yet, it seems to have intensified.

  • That is really good news! To find that something as old as bone broth (cysteine) can mitigate the damage from antibiotic use. When we have proven probiotics help in replenishing the microbiome after antibiotic use. Unfortunately doctors do NOT recommend probiotics with antibiotic use here in New Zealand YET. How sad!

  • Robert

    Sue Detrick, thank you for the info. I have high mast cells and histamine and have been getting unexplained red areas of skin on face, back, etc. I had been drinking ACV a little more and more and will stop. I am also a mold biotoxin person.

  • Karen Scanland

    I took many antibiotics for years, and suspect that is why I cannot lose weight, regardless of diet. What is the fastest and best way to restore the mitochondria? I have been taking NAC for quite a while, but need to do more. Thanks.

    • David Perlmutter

      This protocol is intended to help do just that. Also consider reading up on the work of Dr. Terry Wahls.

  • Terence Kearns

    I think it’s irresponsible to purport the NAC to mitigate ab damage helps make ab usage okay. It should be a last resort. Ab does waaaaay too much damage to the gut flora to not be considered a last resort. People only now are starting to realise just how important gut health really is – especially with the onslaught of glyphosate and other hostile chemicals that our guts have never had to face before in the history of man.

  • CT

    My husband is undergoing several Mohs treatments for Basal Cell, after each treatment the Doctor prescribes an antibiotic for him to prevent infection. I am concerned with all the antibiotics he is taking and thinks he should stop and just take probiotics, any thoughts or advice would be appreciated. Thank you!

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