Chronic intestinal inflammation alters hippocampal neurogenesis

Publication

Journal of Neuroinflammation

Author(s)

Svetlana Zonis, Robert N Pechnick, Vladimir A Ljubimov, Michael Mahgerefteh, Kolja Wawrowsky, Kathrin S Michelsen and Vera Chesnokova

Abstract

Adult neurogenesis in the subgranular zone of the hippocampus is involved in learning, memory, and mood control. Decreased hippocampal neurogenesis elicits significant behavioral changes, including cognitive impairment and depression. Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the intestinal tract, and cognitive dysfunction and depression frequently occur in patients suffering from this disorder. We therefore tested the effects of chronic intestinal inflammation on hippocampal neurogenesis.

Date

April 3, 2015

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