The Empowering Neurologist – David Perlmutter, MD and Dr. Thomas Seyfried

Despite so many highly publicized breakthroughs in medical science, cancer remains a formidable disease. Deaths from cancer are actually continuing to rise, at a rate of 3.5 to 4% each year.

My interview today is with Dr. Thomas Seyfried. Dr. Seyfried believes cancer isn’t primarily caused by damage to the genes living in the nucleus of the cell, a widely held belief, but rather represents a problem of how cells produce energy from their mitochondria. Ultimately, this defective energy production leads to increased free radical production which may then go on to damage the DNA of the cell nucleus as a secondary event.

What is so elegant and compelling about his theory is that it lends itself to a powerful interventional approach centered on simply shifting the energy source of the mitochondria to products derived from fat, as opposed to carbohydrates.

Dr. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois and also holds a Master’s degree in Genetics from Illinois State University He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine, and then served on the faculty as an Assistant Professor in Neurology. Prior to receiving full professorship, Dr. Seyfried was an Associate Professor in the Department of Biology at Boston College. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, and the Journal of Lipid Research. Dr. Seyfried’s research program focuses on gene environmental interactions related to complex diseases, such as epilepsy, autism, brain cancer, and neurodegenerative diseases. Dr. Seyfried investigates many of these diseases from the perspective of, genetics, and energy metabolism. Much of his work, gratefully, also has direct translational benefit to the clinic.

This is a somewhat science-based discussion, but hang in there as there are some critically important gems of information that we get from Dr. Seyfried. Finally, in the broadcast, Dr. Seyfried mentions a book on this subject that’s  geared to a less scientifically minded community. The book is entitled, Tripping Over the Truth, by Travis Christofferson.

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  • Loni Hart

    Thank you very much for bring this to light ! Sad that not only has very little progress been made Cuba beat us to a viable lung caner treatment and, despite paying as much as nearly all the 192 UN nations combined for healthcare the US has fallen to 42nd in global life span reflecting we are on the wrong path, medically speaking. SOURCES: https://www.cia.gov/library/Publications/the-world-factbook/rankorder/2102rank.html & Evidence easier access to over prescribing US rained doctors may NOT be a benefit: Young white males with highest access to medical care in the US lost 10 years on their life span..
    https://www.nytimes.com/2015/11/03/health/death-rates-rising-for-middle-aged-white-americans-study-finds.html?_r=0

  • Loni Hart

    I have noticed a drop in US life span compared globally (42nd now~ WHO stated 33rd 10 years ago before the push for vaccines and opiates) and large up tick in drug over dose. When you over lay it with lobbyist money there does appear a commonality. THis may be a clue as to why the FDA claims it’s just a matter of manpower yet they have a “fast track” for lobbied drugs.. Every time a government agency fails, it wants more funding. Well, I have news for you. The EMA’s annual budget is €322.1 million, which is a little over $342 million in U.S. dollars. By comparison, the FDA’s annual budget was $4.9 billion in fiscal year 2016. That means the FDA spent 14 times more money to have a drug waiting list 168 times the size of Europe’s! https://uploads.disquscdn.com/images/3d62faebd4a8bba91e56394045fa7379c581e169a3e5d806a6ec2855441eb20e.jpg

  • Donna Fuller

    Excellent speaker! As a Registered Nurse Consultant, who has had 2 battles with cancer…This has confirmed many of my beliefs, that were in fact, not popular within standard medical communities. Thank you so much for sharing with us!

    • David Perlmutter

      Yes he is! Thanks for listening.

  • Gela K

    Brilliant interview. Love Dr. Seyfried. He has been beating that same message for a while. Oncology treatment is very,very slow to change. Thanks for having him on.

    • David Perlmutter

      Great to be able to talk with someone on the “front lines”. Thanks for watching our discussion.

  • Peter de Ruyter

    Fantastic video; so many of the dots connected.

    Don’t forget though, the awful impact high dose steroids have on the immune system too, the latter being one of the pillars of a more naturopathic/wholistic approach to cancer.

    Cripple the immune system – which Chemo, steroids and many medical drugs do – and we shoot ourselves in the foot as far as being able to effectively turn a person’s cancer around – in the long-term.

    Re. the reason why Big Chemo-Pharma ain’t gonna underwrite research into metabolic approaches – such as IPT (Insulin Potentiation Therapy) – is at core an economic one. No company who presently manufactures Chemo – to be used at “full dose” – is going to support any therapy that ends up using only about a 1/10th the “normal” chemo dose! Bluntly put… it doesn’t draw in the megabuck!

    Our entire medical research approach – driven in such a major way by the incentive of the “Almighty Dollar” – is inherently anti-science; genuine science that is, which should be driven instead by a core need to discover or explore the best therapeutic solutions – whether they are patentable or not in the end!

    The other major impediment to a more wholistic approach to cancer – research as well as treatment-wise – is the simple fact that science – (with cancer research as just one example) – is still utterly mired in a Newtonian, reductionistic, disconnective world view of how things truly work.

    Why is it, now about 80+ years since Quantum Physics first hit the scientific scene, that most doctors, and most medical researchers still haven’t opened their “playing field” by – NOT abandoning Newtonian Physics – but by INCLUDING a more Quantum Physics (wholistic) approach to viewing our reality??

    Talk about a myopically driven, “scientific dinosaurism”!

    Bravo Dr. Perlmutter for being such a powerful and empowering “paradigm-shifter”. We desperately need more of you guys!

  • steve5960

    dr. perlmutter, much of dr. seyfried’s information applies to the cause of ALS also.

  • catherine

    Thank you so much for this wonderful interview, I’ve learned so much. I have a question though, does taking L-Glutamine to help to repair your intestinal membrane is detrimental -like sugar- to the mitochondria? Thanks!

  • Rochelle

    Amazing interview! Thank you so much.

    • David Perlmutter

      Thanks for watching!

  • blanka

    I would like to find out about the glucose/ketone index calculator, is it a devise or a formula to calculate?

  • Michelle Morris-Phy

    Thank you Dr Seyfried for caring enough to continue to spread your message. And to you Dr Perlmutter for looking outside the box. Praying this is accurate as I use these methods to stop the growth of the tumor in my brain.

  • sip Visser

    I was wondering if I could get the interviews in a transcript form? Im always learning in the night when my children are asleep in the same bed. Funny lifestyle. Sip

    • David Perlmutter

      We are working to make these available Sip. Stay tuned.

  • Anastasia Webber

    Thank you very much for this, really interesting stuff. I am curious how often one would do the 4-5 day fast?

  • Julie Gale

    Again a great coversation Dr Perlmutter, particulaly about prevention.

  • David Minkoff

    Dear Dr Perlmutter,
    I have a cancer clinic in Tampa Bay and we use the Ketogenic diet and low dose chemo with insulin and other holistic therapies. I am very familiar with Dr Seyfried and his work. This is the best interview of him I have ever seen in explaining the principles of treating cancer that actually can work. I commend you for your excellent job. Thanks very much. The more patients and doctors that see this the better as it will mean better outcomes for patients and their families. With my admiration,
    David Minkoff MD
    Lifeworks Wellness Center,
    Clearwater, Florida

  • Gabrielle Heard

    I have passed on the information – more important knowledge hoping that others will listen and understand. Thank you again so much for your Grain Brain , and to Dr Seyfried’s brilliant sharing of his book and explaining so clearly.

    • David Perlmutter

      Sharing this information is one of the most important things we can do. Thank you.

  • Sharon Reynolds Holmes

    Thanks for posting this video. As a nurse, I really appreciated this video.

    • David Perlmutter

      Thanks for watching!

  • Bennett C. Stewart

    Have been reading Travis Christofferson’s book Tripping Over the Truth and it is fascinating. It is interesting how cancer research and research into metabolic diseases such as type II diabetes are dovetailing. There is great room for hope that prevention of alzheimer’s, cancer and diabetes will be greatly enhanced by our diet and maintenance of a healthy biome and mitochondria. Thank you for this most interesting video with Thomas Seyfried.

  • Violet Parkersmith

    My dog has fibrosarcoma maxilla given 6 months I did get your utube of raw meat diet. I think she is way become to help her. Her nose is on left side is now she can not see over her left eye. This cancer tumor is starting to cover her gums. I was given anti inflammatory meds keep her comfy and happy. I can send you photos of her but do not know were to send them to you or add them here. Her cancer stared end of December seen at the vet with test early January sent to Oncologist early Feb. Given Rimadyl I have tried everything nu vet vitamins cdcv natural hemp goes on. Thank you for any information you can give me.

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