FBPixel The Beneficial Role of Vitamin D in Alzheimer’s Disease - David Perlmutter M.D.

Science

Study Title
The Beneficial Role of Vitamin D in Alzheimer’s Disease
Publication
American Journal of Alzheimer's Disease
Author(s)

Khanh Vinh Quo c Lu’o’ng, MD, FACP, FACE, FACN, FASN, FCCP, FACAAI; Lan Thi Hoang Nguyen, MD

Abstract

Alzheimer’s disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive neurodegeneration of the human neocortex. Patients with AD have a high prevalence of vitamin D deficiency, which is also associated with low mood and impaired cognitive performance in older people. Genetic studies have provided the opportunity to determine which proteins link vitamin D to AD pathology (ie, the major histocompatibility complex class II molecules, vitamin D receptor, renin–angiotensin system, apolipoprotein E, liver X receptor, Sp1 promoter gene, and the poly(ADP-ribose) poly- merase-1gene). Vitamin D also exerts its effect on AD through nongenomic factors, that is, L-type voltage-sensitive calcium chan- nels, nerve growth factor, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide synthase. In conclusion, vitamin D clearly has a beneficial role in AD and improves cognitive function in some patients with AD. Calcitriol, 1a,25- dihydroxyvitamin D3, is best used for AD because of its active form of vitamin D3 metabolite and its receptor in the central nervous system.

Date
December 1, 2017
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Dr. David Perlmutter is on the cutting edge of innovative medicine that looks at all lifestyle influences on health and illness.

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