The Empowering Neurologist – David Perlmutter, MD and Dr. Dale Bredesen

We fear Alzheimer’s as we fear no other disease for two reasons. It is the only all one of the nation’s ten most common causes of death for which there has been no effective treatment. And it is not only fatal: it robs its victims of their lives long before they are gone. But Dale E. Bredesen, MD, has turned the tables, showing that Alzheimer’s disease and cognitive decline can not only be prevented but, in many cases, reversed. Now, in this paradigm-shifting book, he brings hope, and the first good news, to Alzheimer’s patients, with a new understanding of the disease and a new program they can put into effect themselves. Dr. Bredesen reveals that Alzheimer’s is not one condition, as it is currently treated, but several. They are driven by different mechanisms and typically manifest in different ways and at different ages. But all are dramatically influenced by imbalances in thirty-six metabolic factors that can trigger “downsizing” in the brain. He then explains his research-based protocol, which addresses ways to rebalance these mechanisms by adjusting lifestyle factors; including micronutrients, hormone levels. stress, and sleep quality. He explores the critical role of diet in cognitive decline as well as the importance of autophagy, which involves a strict overnight fast. The results have been impressive. Of the first ten patients on the protocol, nine displayed significant improvement within three to six months; since then the protocol has yielded similar results with hundreds more. With wide-ranging patient stories that allow us to understand what it’s like to recover when recovery is deemed impossible, and specific information that will help patients, caregivers, physicians, and treatment centers put the protocol into action, this book will fundamentally change how we treat, prevent, and even think about Alzheimer’s disease.

The above quote is found on the inside cover of Dr. Dale Bredesen’s new book, The End of Alzheimer’s – The First Program to Prevent and Reverse Cognitive Decline.

It’s my great honor and privilege to interview Dr. Bredesen for today’s segment of The Empowering Neurologist. I have known Dr. Bredesen for many years and have followed his work closely. He is clearly a pioneer and trailblazer, but more importantly, he is not afraid to challenge the mainstream medical world’s fixation with developing magic bullets, especially as it relates to dealing with a disease like Alzheimer’s. Rather, he has developed a far more comprehensive program that is proving successful – finally!

The End of Alzheimer’s has been wonderfully received for its profound scientific foundations, but it is written in a way that is understandable and, more importantly, functional in terms of allowing all of us to make important changes to protect our brains.

Today’s interview is very important as it crystallizes so much work that has been taking place over the past decade in understanding neurodegenerative conditions.

  • Joel Chudnow, Wholistic Health

    Please indentify the connection of Yaacov Croytzfeld Disease (Mad Cow)-encephalopathy to Alzheimer’s. Our nation’s ravenous overconsumption of dead animal flesh is certainly a possible link.
    Thank you.

  • Gayle63

    Regarding chronic pathogens, there could very well be a connection between Lyme and AD. Dr. Alan MacDonald has an excellent three-part series about Lyme on YouTube that is worth watching. Also, DDT exposure appears to be connected to AD.

  • Kat Milacek

    Excellent interview. I have read his new book (excellent!) and have it on Audible to listen to as well. So I thought I might not get much more out of this interview. I almost didn’t listen to it, but I’m so glad I did. I learned more about the concerns, and future research, looking into some of the pathogens – of which I have had exposure to some. So am always interested to learn more. I have e-mailed his office staff several times over the past few years to try to find someone in/near Dallas, TX that I could see as my physician. Still trying to find someone locally. He just had a training course here this past month or so, so hopefully some of those physicians will be added to the lists soon. Appreciate all the great research and work he’s doing, and bucking the system too.

  • Dear Dr. David, What about dramatically “upsizing” the brain using specific mental stimulation? Please view http://www.CreateK12Change.com As children we are not taught how to memorize so we do not take advantage of the opportunity during K-12 Education to stimulate our brain’s hippocampus. This is my Scientific Hypothesis: At any age, one’s hippocampus can be positively stimulated by learning, practicing, and mastering 1 proven, dependable, and repeatable method for Memorizing and Creating. I’d greatly appreciate an opportunity to speak with you about this. Thank you! Russell

  • AnnieLaurie Burke

    It is interesting that, in all the cutting-edge success treating so-called “incurable diseases — Alzheimer’s, MS, intractable cancers such as glioblastoma — the ketogenic/low-carb diets, and the importance of high-quality fats in the diet, keep emerging as a critical factor in the therapies that are working. Yet, as we have seen in responses to many of Dr. P’s blogs, there are still low-fat apologists that deny the evidence, much as the radiologist Dr. Bredesen described refused to acknowledge the photographic evidence of the patient’s improvement. It would be interesting to look at the long-term cognitive health of people who followed the LFHC regimen to reduce their CVD risk (although a LFHC diet is by no means the only way to change one’s CVD risk).

  • Ruth Robertson

    I just love the momentum that is happening with this I hope it can continue. I am certainly trying to put the word out. Keep up the good work!

    • David Perlmutter

      Absolutely. We must continue to share this science!

  • Catherine Dignan

    Dr Bredesden mentioned practitioner training in the Bredesden protocol run by the IMF in London in April 2018. I have visited the IMF website but it is not listed. Does anyone have further information?

    • David Perlmutter

      You would have to stay tuned to their website Catherine. Can’t say I know much more.

  • Renata Kowalski

    Hi Dr. Perlmuter,
    My family and I have been benefiting from alternative medicine for about 30 years, which has been functioning as preventive medicine in order to keep our good health.
    We always paid for these services, since health insurance does not cover alternative medicine, and I understand perfectly why. After hearing Dr. Bredesen addressing funcional and integrative medicine as the treatment for Alzheimer’s disease, I was wondering if there is any movement and effort towards health care in the US including alternative and functional treatments?

  • Sorina Kunert

    Thank you so much for this Interview.
    I am working in Berlin, Germany. I am just reading the Book. How can I train Dr. Bredesen’s Protocol ? Thank you for helping.
    Dr.med. Sorina Kunert MSc.In Preventive Medicine

  • Donna Lutsky

    Hi Dr. Perlmutter, I had a chance to say hello to you at your talk in Denver. The interview with Dr. Bredesen was excellent. Thanks again for doing the kind of work that you do and sharing it with the public and with professionals; very exciting, cutting edge.

    • David Perlmutter

      Thank you for watching Donna!

  • Loretta

    A few comments: No. 1, I found it puzzling that Dr. Perlmutter seemed to endorse the continued use of medications for Alzheimer’s when he said in his introduction to the interview that they “do nothing to change the ultimate course of events that an Alzheimer’s patient will experience.”

    No. 2, In looking through my files I have found that in the 1980s a duly-diagnosed Alzheimer’s patient named Tom Warren wrote a book about his own reversal of the illness. He began a program that included the removal of all his amalgam fillings, testing for food allergies, and a switch to an organic, whole foods diet. Additionally, Tom followed a nutritional supplementation program, a regular exercise program, and a complete avoidance of household chemical pollutants. In 1987 a CAT scan indicated that his disease had been reversed. His book was called Beating Alzheimer’s. I wonder if Dr. Bredesen or Dr. Perlmutter was aware of this earlier triumph over the disease that never got the recognition that Dr. Bredesen is getting?

    No. 3, again in looking through my files, I have found another book, this one with the same title as Dr. Bredesen’s: The End of Alzheimer’s, this one written by Thomas J. Lewis, Ph.D., and Clement J. Trempe, M.D, and the book is described as a “First-of-Its-Kind, Whole-Body Approach to Slow, Stop, and Reverse Alzheimer’s and Dementias.” It was published in 2014 or 2015. Again, I wonder if Drs. Bredesen and Perlmutter are aware of this earlier book with the same bold title that Dr. Bredesen gave his book a couple of years later?

    All this having been said, I wonder about one more thing: Is Dr. Bredesen, perhaps in conjunction with these other pioneers, eligible for a Nobel prize in medicine, or is that process one that is reserved for those with magic bullet approaches? Surely, his work and the work of the others are worthy of such a distinction. Do we dream needlessly or is there a possibility of such a reward for such needed, logical, and effective treatment for what the conventional world is still calling a disease without known cause and with no cure?

  • taffytee

    In which book of Dr. Bredesen’s is his protocol described in detail?

    • David Perlmutter

      His latest book, End of Alzheimer’s: http://amzn.to/2yyF6li

      • taffytee

        Thank you so very much for answering, and so promptly. I greatly appreciate the work you and Dr. Bredesen and others are doing. I have young cardiologist, rheumatologist and dermatologist as “children”, and they do say that medical school does not teach them sufficiently in nutrition, and that the basic science professors push too much detail in their courses for the general MD training. They are open to discussing the concerns re: dementia and reduced fat intake but, especially the cardiologist, wants hard evidence that statins are harmful. He thinks they protect against stroke, and that living with a stroke-damaged brain and body is just as bad as dementia. Any particular references for me to give him? (I’m constantly reading articles that I can access on PubMed, but admittingly, cannot interpret the statistics well.)

  • Mitzi Andersen

    Following the protocols of Drs Bredesen and Perlmutter, and with the help of my kind General Practitioner (no functional practioners here in South Africa at the time), I was able to reverse my husband’s Alzheimer’s. Sadly, it became clear that he was also in the late stages of Parkinson’s (PD). He died of aspiration pneumonia at age 80. His neurologist may have known of the condition much earlier. This is not to criticise a very kind man but to raise the point that Alzheimer’s gets attention in a way that Parkinson’s doesn’t. I have a strong feeling that Parkinson’s is also multifactorial but so many people with PD are still desperately waiting for a magic-bullet. Are you aware of any programmes like Dr Bredesen’s for people with PD?

    • David Perlmutter

      So wonderful to hear of his health turnaround. Wishing you both continued good health.

      • Mitzi Andersen

        Dr Perlmutter, sadly he died at 80 of Parkinson’s in January two months after diagnosis.
        I have kept in touch with a Parkinson’s support group and note how most of them are waiting anxiously for a magic bullet. I have a strong feeling that Parkinson’s is multifactorial like Alzheimer’s and would also respond to a many-pronged approach. Unfortunately, while Alzheimer’s is getting much attention, there does not seem to be an equivalent approach with Parkinson’s. Do you know of any such focus?

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